Trip12 gcase
WebMay 7, 2024 · Thyroid hormone receptor interactor 12 (TRIP12) is an E3 ligase most notably involved in the proteolytic degradation of the tumor suppressor p14ARF. Through this process, it is proposed that TRIP12 plays an oncogenic role in tumor initiation and growth. However, its role in other cancer processes is … WebTrip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response The deubiquitinating enzyme, USP7/HAUSP (herpesvirus-associated ubiquitin-specific …
Trip12 gcase
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WebApr 6, 2024 · The tumor suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF) and itself a target for ubiquitylation. Here, the authors show that TRIP12 mediates ... Web3612 N Tripp Ave, Chicago, IL 60641 is currently not for sale. The 1,300 Square Feet apartment home is a 2 beds, 1 bath property. This home was built in null and last sold on …
WebOct 12, 2024 · Europe PMC is an archive of life sciences journal literature. WebApr 1, 2024 · Thus, TRIP12 and K29/K48-branched ubiquitin chains act as facilitators of neo-substrate degradation, rather than critical components of this process. The authors speculate that substrate degradation in the absence of TRIP12 may be a result of redundant functions between other ubiquitin chain branching/elongating E3 ligases
WebDec 1, 2024 · TRIP12 accumulation affects mitochondria function and α-syn aggregate formation by acting via GCase. GCase functional impairment is associated with … WebThe Thyroid hormone Receptor Interacting Protein 12 (TRIP12) protein belongs to the 28-member Homologous to the E6-AP C-Terminus (HECT) E3 ubiquitin ligase family. First described as an interactor of the thyroid hormone receptor, TRIP12’s biological importance was revealed by the embryonic lethality of a murine model bearing an …
WebDepleting TRIP12 in the human dopaminergic neurons and SN provides neuroprotection against α-synuclein preformed fibrils-provoked PD by increasing the GCase activity. This …
WebWe discovered TRIP12, a ubiquitin E3 ligase, as a major regulator of wt GCase turnover. We uncovered that TRIP12 tightly controls the GCase level via the ubiquitin-proteasome … fnf well well well copypastaWebTo further investigate the function of Trip12, we generated two Trip12mt/mt ES cell clones [17 and #2] (Fig. 3A, 3B, and 3C). We examined the ability of Trip12mt/mt ES cells to self-renew and differentiate. The expression levels of Nanog and Oct-4 were comparable in the two Trip12mt/mt ES cell clones and wild-type cell cultures with or without ... greenwashing définition englishWebIn this paper, we identify the E3 ligase Thyroid Hormone Receptor Interacting Protein 12 (TRIP12) as a key regulator of GCase. TRIP12 interacts with and ubiquitinates GCase at … greenwashing diaporamaWebThe E3 ligase TRIP12 interacts with and ubiquitinates GCase associated with the development of PD. The ubiquitinated GCase by TRIP12 leads to its functional impairment, and subsequent accumulation of α-synuclein and mitochondrial dysfunction. TRIP12 depletion promotes the expression of GCase, which blocks dopaminergic … greenwashing definition oxford dictionaryWebTRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease. Bo Am Seo, Donghoon Kim, Heehong Hwang, Min Seong Kim, Shi Xun Ma, Seung Hwan Kwon, Sin Ho Kweon, Hu Wang, Je Min Yoo, Seulah Choi, ... fnf well made winWebIn this paper, we identify the E3 ligase Thyroid Hormone Receptor Interacting Protein 12 (TRIP12) as a key regulator of GCase. TRIP12 interacts with and ubiquitinates GCase at lysine 293 to control its degradation via ubiquitin proteasomal degradation. Ubiquitinated GCase by TRIP12 leads to its functional impairment through premature ... greenwashing definition gablerWebThe TRIP12 gene plays a key role in the basic function of the cell. Symptoms Because the TRIP12 gene is important in the development and function of brain cells, many people who have TRIP12-related syndrome have: Intellectual disability Speech delay Autism Do people who have TRIP12-related syndrome look different? fnf well well well fnf