Cisplatin induced toxicity
WebOleuropein Ameliorates Cisplatin-induced Hematological Damages Via Restraining Oxidative Stress and DNA Injury Oleuropein Ameliorates Cisplatin-induced Hematological Damages Via Restraining Oxidative Stress and DNA Injury Indian J Hematol Blood Transfus. 2024 Sep;33 (3):348-354. doi: 10.1007/s12288-016-0718-3. … WebAug 9, 2024 · Cisplatin, despite its anti-cancer ability, exhibits severe testicular toxicities when applied systemically. Due to its wide application in cancer treatment, reduction of its damages to normal tissue is an imminent clinical need.
Cisplatin induced toxicity
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WebOf these reactions, cisplatin-induced nephrotoxicity (CIN), cisplatin-induced peripheral neuropathy (CIPN), and cisplatin-induced ototoxicity (CIO) are the three most common of several CITs recognised thus far. While the anti-cancer activity of cisplatin is well understood, the mechanisms driving its toxicities have only begun to be defined. WebA major problem besides cisplatin resistance (occurring in nearly one-third of patients) is the greater toxicity of the drug combinations. A synergistic treatment with drug supporting activity could maximize the cytotoxic effects of chemotherapeutic agents on tumor cells while decreasing the dosage of each drug to potentially reduce toxicity.
WebFeb 11, 2024 · Cisplatin is used to treat a wide range of childhood cancers and cisplatin-induced hearing loss (CIHL) is a common and debilitating toxicity. We aimed to address persistent knowledge gaps in CIHL by establishing benchmarks for the prevalence of and risk factors for CIHL. Methods WebApr 28, 2024 · Cisplatin-Induced Reproductive Toxicity and Oxidative Stress: Ameliorative Effect of Kinetin . Authors Rania Abdel-Latif 1 , Moustafa Fathy 2 , Hend Ali Anwar 2 , Muhammad Naseem 3 4 , Thomas Dandekar 4 , Eman M Othman 2 4 Affiliations 1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Minia, …
WebOxidative stress plays a pivotal role in cisplatin-induced renal damage and several dietary antioxidants have been reported to ameliorate this secondary effect. Relevant findings on the protective effects of these antioxidant agents in cisplatin-induced nephrotoxicity are summarized in this paper. WebCisplatin-induced testicular damage is a major obstacle in the application of cisplatin as chemotherapeutic agent. However, it remains as one of the most widel 掌桥科研 一站式 …
WebJun 22, 2024 · Cisplatin (CisP) is a chemotherapeutic agent used to treat head and neck and lung cancer in adults and over 15 different pediatric cancers. Despite its known …
WebDec 16, 2024 · Cisplatin (CDDP; cis-dichlorodiammine platinum [II]) is a non-specific drug of the cell cycle with strong cytotoxicity and broad-spectrum antitumor effects; it is widely used in urogenital system tumors, malignant lymphoma, breast cancer, head and neck cancer, non-small cell lung cancer, etc. ( 1 – 3) Cisplatin-induced nephrotoxicity is … galvanized pedestrian truss bridgeWebJul 3, 2024 · Cisplatin is widely used for the treatment of a number of solid malignant tumors. However, ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for this toxicity has not been fully elucidated. It is generally accepted that hearing loss is due to excessive production of reactive oxygen species by cells of the … black coffee ice creamWebApr 25, 2014 · The use of cisplatin is frequently limited by various significant side effects such as bone marrow suppression, peripheral neuropathy, ototoxicity, anaphylaxis, and nephrotoxicity. After a single dose of cisplatin (50–100 mg/m2), approximately one-third of the patients develop nephrotoxicity [10, 11]. galvanized pendant light fixturesWebMay 9, 2024 · A general discussion of the clinical presentation, pathogenesis, diagnosis, differential diagnosis, and management of antineoplastic agent-induced pulmonary … black coffee i have faithWebSep 15, 2024 · Common side effects include nausea, vomiting, bone marrow suppression, electrolyte imbalance, neuropathy, ototoxicity and nephrotoxicity. Cisplatin is mutagenic, teratogenic and carcinogenic and its use has been show to increase the risk of secondary malignancies, particularly leukemia. Hepatotoxicity. galvanized pedestal traysWebOct 26, 2005 · Cisplatin-induced cytotoxicity was determined by reduction of 3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) as described previously ( Chen and Cederbaum, 1998 ). Measurement of intracellular GSH. Reduced glutathione (GSH) was assayed using a modified method of Hissin and Hilf (1976). black coffee if fastingWebCisplatin has dramatically improved the survival rate of cancer patients, but it has also increased the prevalence of hearing and neurological deficits in this population. Cisplatin … galvanized pendant barn light