Atorvastatin moa
WebAtorvastatin is an anti-cholesterol medication used to reduce the levels of bad cholesterol (LDL) and also help improve the levels of good cholesterol (HDL) in the … WebAtorvastatin C33H35FN2O5 - PubChem Atorvastatin C33H35FN2O5 CID 60823 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, …
Atorvastatin moa
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WebSep 2, 2024 · Atorvastatin is highly plasma protein bound (over 98%) and has a volume of distribution of about 380 liters. Metabolism Atorvastatin is metabolized by cytochrome P450 3A4 (CYP3A4) to active ortho- and para-hydroxylated metabolites. Excretion Atorvastatin and its metabolites get eliminated in bile. Weblovastatin, pravastatin, simvastatin, rosuvastatin, and atorvastatin Mechanism prevents synthesis of mevalonate, a cholesterol precursor, by inhibiting HMG-CoA reductase this is the rate-limiting step of cholesterol synthesis increases LDL receptors Clinical use ↓ mortality in patients with coronary artery disease
WebMechanism of Action. As with other statins, atorvastatin is a competitive inhibitor of HMG-CoA reductase. Unlike most others, however, it is a completely synthetic compound. HMG-CoA reductase catalyzes the reduction of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) to mevalonate, which is the rate-limiting step in hepatic cholesterol ... WebAtorvastatin is an HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Brand Names. Caduet, Lipitor, Lypqozet. Generic Name. Atorvastatin. DrugBank Accession …
WebApr 1, 2024 · Atorvastatin is used together with a proper diet to lower cholesterol and triglyceride (fats) levels in the blood. This medicine may help prevent medical problems (eg, chest pain, heart attack, or stroke) that are caused by fats clogging the blood vessels. It may also be used to prevent certain types of heart and blood vessel problems in ... WebMechanism of action HMG-CoA reductase inhibitors. Purpose Decrease LDL and VLDL cholesterol. Increase HDL. Therapeutic uses Primary hypercholesterolemia. Prevention of coronary events (primary and secondary). Protection against MI and stroke for those with DM. Increasing HDL in clients who have primary hypercholesterolemia.
WebFor atorvastatin Common or very common Epistaxis; hyperglycaemia; hypersensitivity; joint swelling; laryngeal pain; nasopharyngitis; pain Uncommon Appetite decreased; burping; chest pain; fever; hypoglycaemia; malaise; numbness; peripheral oedema; taste altered; tinnitus; vision disorders; weight increased Rare or very rare
WebRosuvastatin is also a unique member of the class of statins due to its high hydrophilicity which increases hepatic uptake at the site of action, low bioavailability, and minimal metabolism via the Cytochrome P450 system. 37 This last point results in less risk of drug-drug interactions compared to atorvastatin, lovastatin, and simvastatin ... cloudy urine in kidsWebThe beneficial effects of statins are the result of their capacity to reduce cholesterol biosyntesis, mainly in the liver, where they are selectively distributed, as well as to … c3 weatherstrip replacementWebChanges in the microbiome have been linked to atorvastatin treatment in an HFD-induced hypercholesterolemia rat model. 9 Thus, the mechanism of action of atorvastatin was studied by changes in the intestinal microbiome 14 or by analyzing plasma metabolites. 25. We used an HFD-induced rat model to assess the effect of atorvastatin. c3wf8pwaWebSep 2, 2024 · Atorvastatin competitively inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. By preventing the conversion of HMG-CoA to mevalonate, statin medications decrease cholesterol production in the liver. Atorvastatin also increases the number of LDL receptors on the surface of hepatic cells. c3wellness.comWebAtorvastatin (AVA) is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. ... These data could suggest that the mechanism of AVA uptake and/or the mode of action of AVA is different from those for other antimalarial drugs. The IC(50)s for AVA were unrelated to the occurrence of mutations in the transport protein genes involved in ... c3 wervelWebAtorvastatin is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. It belongs to a group of drugs ... c3 weatherstrip removalWebBuy Atorvastatin (Lipitor) Online without Prescription Place your order by 18th December Midday to receive your gifts before Christmas. FREE JOBY 3K KIT WHEN YOU SPEND … cloudy urine in elderly women